Metabolism in Human Immune Cells Signaling and 2-Arachidonoyl-Glycerol Effect of Lipid Rafts on Cb2 Receptor
نویسندگان
چکیده
منابع مشابه
Endocannabinoids enhance lipid synthesis and apoptosis of human sebocytes via cannabinoid receptor-2-mediated signaling.
We had previously shown that both locally produced endocannabinoids and exocannabinoids, via cannabinoid receptor-1 (CB1), are powerful inhibitors of human hair growth. To further investigate the role of the cannabinoid system in pilosebaceous unit biology, we have explored in the current study whether and how endocannabinoids have an impact on human sebaceous gland biology, using human SZ95 se...
متن کاملEndocannabinod Signal Dysregulation in Autism Spectrum Disorders: A Correlation Link between Inflammatory State and Neuro-Immune Alterations
Several studies highlight a key involvement of endocannabinoid (EC) system in autism pathophysiology. The EC system is a complex network of lipid signaling pathways comprised of arachidonic acid-derived compounds (anandamide, AEA) and 2-arachidonoyl glycerol (2-AG), their G-protein-coupled receptors (cannabinoid receptors CB1 and CB2) and the associated enzymes. In addition to autism, the EC sy...
متن کاملThe cannabinoid system and immune modulation.
Studies on the effects of marijuana smoking have evolved into the discovery and description of the endocannabinoid system. To date, this system is composed of two receptors, CB1 and CB2, and endogenous ligands including anandamide, 2-arachidonoyl glycerol, and others. CB1 receptors and ligands are found in the brain as well as immune and other peripheral tissues. Conversely, CB2 receptors and l...
متن کاملDocosahexaenoic Acid Changes Lipid Composition and IL-2 Receptor Signaling in Membrane Rafts Running Title: DHA changes Rafts
Polyunsaturated fatty acids (PUFAs) including docosahexaenoic acid (DHA; 22:6 n-3) modulate immune responses and exert beneficial immunosuppressive effects, but the molecular mechanisms inhibiting T cell activation are not yet elucidated. Lipid rafts have been shown to play an important role in the compartmentalization and modulation of cell signaling. We investigate the role of DHA in modulati...
متن کاملDocosahexaenoic acid changes lipid composition and interleukin-2 receptor signaling in membrane rafts.
Polyunsaturated fatty acids, including docosahexaenoic acid (DHA, 22:6n-3), modulate immune responses and exert beneficial immunosuppressive effects, but the molecular mechanisms inhibiting T-cell activation are not yet elucidated. Lipid rafts have been shown to play an important role in the compartmentalization and modulation of cell signaling. We investigated the role of DHA in modulating the...
متن کامل