ncillary Therapy and Supportive Care of Chronic raft-versus-Host Disease: National Institutes of ealth Consensus Development Project on Criteria or Clinical Trials in Chronic Graft-versus-Host isease: V. Ancillary Therapy and Supportive Care orking Group Report
نویسندگان
چکیده
The Ancillary Therapy and Supportive Care Working Group had 3 goals: (1) to establish guidelines for ancillary therapy and supportive care in chronic graft-versus-host disease (GVHD), including treatment for symptoms and recommendations for patient education, preventive measures, and appropriate follow-up; (2) to provide guidelines for the prevention and management of infections and other common complications of treatment for chronic GVHD; and (3) to highlight the areas with the greatest need for clinical research. The definition of “ancillary therapy and supportive care” embraces the most frequent immunosuppressive or anti-inflammatory interventions used with topical intent and any other interventions directed at organ-specific control of symptoms or complications resulting from GVHD and its therapy. Also included in the definition are educational, preventive, and psychosocial interventions with this same objective. Recommendations are organized according to the strength and quality of evidence supporting them and cover the most commonly involved organs, including the skin, mouth, female genital tract, eyes, gastrointestinal tract, and lungs. Recommendations are provided for prevention of infections, osteoporosis, and steroid myopathy and management of neurocognitive and psychosocial adverse effects related to chronic GVHD. Optimal care of patients with chronic GVHD often requires a multidisciplinary approach. © 2006 American Society for Blood and Marrow Transplantation he opinions expressed here are those of the authors and do not represent the official position of the National Institutes of Health, Food and Drug dministration, or the United States Government.
منابع مشابه
istopathologic Diagnosis of Chronic raft-versus-Host Disease: National Institutes of ealth Consensus Development Project on Criteria or Clinical Trials in Chronic Graft-versus-Host isease: II. Pathology Working Group Report
This consensus document provides an update for pathologists and clinicians about the interpretation of biopsy results and use of this information in the management of hematopoietic cell transplantation patients. Optimal sampling and tissue preparation are discussed. Minimal criteria for the diagnosis of graft-versus-host disease (GVHD) are proposed, together with specific requirements for the d...
متن کاملBIOMARKERS FOR CHRONIC GRAFT VERSUS HOST DISEASE National Institutes of Health Consensus Development Project on Criteria for Clinical Trials in Chronic Graft-Versus-Host Disease: III Biomarker Working Group Report Running title: Biomarkers and chronic GVHD
متن کامل
easuring Therapeutic Response in Chronic raft-versus-Host Disease: National Institutes of ealth Consensus Development Project on Criteria or Clinical Trials in Chronic Graft-versus-Host isease: IV. Response Criteria Working Group Report
The lack of standardized criteria for quantitative measurement of therapeutic response in clinical trials poses a major obstacle for the development of new agents in chronic graft-versus-host disease (GVHD). This consensus document was developed to address several objectives for response criteria to be used in chronic GVHD-related clinical trials. The proposed measures should be practical for u...
متن کاملoward Biomarkers for Chronic Graft-versus-Host isease: National Institutes of Health Consensus evelopment Project on Criteria for Clinical Trials n Chronic Graft-versus-Host Disease: III. Biomarker orking Group Report
Biology-based markers that can be used to confirm the diagnosis of chronic graft-versus-host disease (GVHD) or monitor progression of the disease could help in the evaluation of new therapies. Biomarkers have been defined as any characteristic that is objectively measured and evaluated as an indicator of a normal biologic or pathogenic process, a pharmacologic response to a therapeutic interven...
متن کاملRecognizing and managing chronic graft-versus-host disease.
Chronic graft-versus-host disease (GVHD) is an immune-mediated disorder that occurs frequently after allogeneic hematopoietic cell transplantation (HCT). Most cases are diagnosed within the first year at a median of 4 to 6 months after HCT, but 5-10% of cases are initially diagnosed beyond the first post-transplant year. Chronic GVHD most often involves the skin and mouth, but almost any other ...
متن کامل