Salivary microvesicles clot blood.

نویسنده

  • Peter L Gross
چکیده

The capacity of saliva to clot blood has been documented in the scriptures (Luke 16:21), folklore, and in the medical literature of the 1920s when Hunter described the ability of saliva to clot blood and proposed it as a means to attenuate bleeding from gastric ulcers.1 In 1938, Glazko and Greenberg reported that saliva contains a cell-derived, protein-based thromboplastin,2 which was later identified as tissue factor.

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

Breast Cancer Exosome-like Microvesicles and Salivary Gland Cells Interplay Alters Salivary Gland Cell-Derived Exosome-like Microvesicles In Vitro

Saliva is a useful biofluid for the early detection of disease, but how distal tumors communicate with the oral cavity and create disease-specific salivary biomarkers remains unclear. Using an in vitro breast cancer model, we demonstrated that breast cancer-derived exosome-like microvesicles are capable of interacting with salivary gland cells, altering the composition of their secreted exosome...

متن کامل

Membrane microvesicles: a circulating source for fibrinolysis, new antithrombotic messengers.

Thrombus lysis is the consequence of a restricted number of reactions localized on the surface of fibrin and cell membranes. A functional defect or an insufficient fibrinolytic response may lead to thrombosis with severe or fatal clinical consequences. Despite this clinical need, and real progress in the knowledge of the different components of this system (plasminogen activators, inhibitors an...

متن کامل

Active tissue factor pathway inhibitor is expressed on the surface of coated platelets.

The incorporation of blood-borne forms of tissue factor (TF) into a growing blood clot is necessary for normal fibrin generation and stabilization of the blood clot. Tissue factor pathway inhibitor (TFPI) is the primary physiologic inhibitor of tissue factor and is present within platelets. Expression of TFPI on the platelet surface may be the optimal location for it to abrogate blood-borne TF ...

متن کامل

HEMOSTASIS, THROMBOSIS, AND VASCULAR BIOLOGY Active tissue factor pathway inhibitor is expressed on the surface of coated platelets

The incorporation of blood-borne forms of tissue factor (TF) into a growing blood clot is necessary for normal fibrin generation and stabilization of the blood clot. Tissue factor pathway inhibitor (TFPI) is the primary physiologic inhibitor of tissue factor and is present within platelets. Expression of TFPI on the platelet surface may be the optimal location for it to abrogate blood-borne TF ...

متن کامل

Use of a Flexible Cryoprobe for Removal of Tracheobronchial Blood Clots.

Acute obstruction of the central airways can occur due to foreign-body inhalation, mucus plugs, or blood clots. Airway obstruction due to blood clots is clinically suspected in a patient with acute respiratory failure if the patient has hemoptysis. However, one third of patients with acute endobronchial obstruction due to blood clots may present without obvious hemoptysis.1,2 Management involve...

متن کامل

ذخیره در منابع من


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

عنوان ژورنال:
  • Blood

دوره 117 11  شماره 

صفحات  -

تاریخ انتشار 2011