The diagnostic importance of invasive micropapillary carcinoma in the canine mammary gland: clinicopathological, immunohistochemical and survival analysis
نویسندگان
چکیده
Results Of the 22 studied cases, the majority had > 3 cm neoplasms (15/19, 78.95%) and lymph node metastases (16/16, 100%), but only two cases (2/9, 22.2%) had distant metastases. The IMPCs were classified as either pure (15/22, 68.18%) or mixed (7/22, 31.82%) types. A predominance of moderate histological grade (16 grade II) tumours was observed and the average overall survival was 120 days. Positive immunohistochemical staining for EMA and negative staining for CD-31, p63 and CK AE1AE3 in cystic formations confirmed the micropapillary nature of these neoplasms. The majority of cases were positive for RE (19/20, 95%) and RP (19/20, 95%), but lacked HER-2 (16/ 22, 72.72%) and EGFR (15/22, 68.18%) over-expression.
منابع مشابه
Classification and grading of canine malignant mammary tumors
Histological grading is a good parameter to stratify tumors according to their biological aggressiveness. The Elston and Ellis grading method in humans, invasive ductal breast carcinomas and other invasive tumors are routinely used. The aims of this study were classification of mammary gland tumors and also application of a human grading method in canine mammary carcinoma. The samples included ...
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