The Mechanism of Intrinsic Amplification of Hyperpolarizations and Spontaneous Bursting in Striatal Cholinergic Interneurons

Complex autonomous firing patterns of striatal low-threshold spike interneurons.

During sensorimotor learning, tonically active neurons (TANs) in the striatum acquire bursts and pauses in their firing based on the salience of the stimulus. Striatal cholinergic interneurons display tonic intrinsic firing, even in the absence of synaptic input, that resembles TAN activity seen in vivo. However, whether there are other striatal neurons among the group identified as TANs is unk...

Complex autonomous firing patterns of striatal low - threshold 1 spike interneurons

19 During sensorimotor learning, tonically active neurons (TANs) in the striatum acquire bursts 20 and pauses in their firing based on the salience of the stimulus. Striatal cholinergic interneurons 21 display tonic intrinsic firing, even in the absence of synaptic input, that resembles TAN activity 22 seen in vivo. But whether there are other striatal neurons among the group identified as TANs...

Origin of the slow afterhyperpolarization and slow rhythmic bursting in striatal cholinergic interneurons.

Striatal cholinergic interneurons recorded in slices exhibit three different firing patterns: rhythmic single spiking, irregular bursting, and rhythmic bursting. The rhythmic single-spiking pattern is governed mainly by a prominent brief afterhyperpolarization (mAHP) that follows single spikes. The mAHP arises from an apamin-sensitive calcium-dependent potassium current. A slower AHP (sAHP), al...

Rhythmic Bursting in Striatal Cholinergic Interneurons Origin of the Slow Afterhyperpolarization and Slow

Striatal Cholinergic Interneurons Control Motor Behavior and Basal Ganglia Function in Experimental Parkinsonism.

Despite evidence showing that anticholinergic drugs are of clinical relevance in Parkinson's disease (PD), the causal role of striatal cholinergic interneurons (CINs) in PD pathophysiology remains elusive. Here, we show that optogenetic inhibition of CINs alleviates motor deficits in PD mouse models, providing direct demonstration for their implication in parkinsonian motor dysfunctions. As neu...