Threat to Cefixime Treatment for Gonorrhea
نویسندگان
چکیده
Emerging Infectious Diseases • www.cdc.gov/eid • Vol. 13, No. 8, August 2007 1275 increase SLE incidence in Louisiana, and if it did increase incidence in Mississippi, the increase was minimal. In both 2003 and 2004, Louisiana’s median reporting time to ArboNET was ≈30 days. In 2005, the median reporting time prehurricane was 36 days and posthurricane was 69 days. Louisiana state offi cials believed that this reporting lag was largely due to impaired transport and collection of biologic samples and relocation of diagnostic facilities immediately following the hurricane. In contrast, in 2003 and 2004, Mississippi’s median reporting time to ArboNET was 21 days and 36 days, respectively. In 2005, the median reporting time prehurricane was 23 days and posthurricane was 14 days. Mississippi state offi cials believed that the improved reporting time was due to the additional help and longer hours worked by health department offi cials following the hurricane. Although Hurricane Katrina disrupted WNV surveillance in Louisiana, it did not appear to increase the incidence of WNND and SLE in either Louisiana or Mississippi. In coastal areas, the hurricane destroyed housing and impeded vector control, thus possibly increasing the risk of mosquito-borne infections (1,2). However, hurricane-force winds and heavy fl ooding might have actually decreased the risk of WNV and SLE transmission by dispersing or killing birds and mosquitoes, and destroying their habitat. Many people were promptly evacuated to less affected areas, where, on the basis of previous years’ data showing seasonality of WNV transmission, the risk of infection was probably decreasing. Natural disasters do not usually cause an immediate increase in arboviral diseases (1,2). However, if hurricanes strike early in transmission season, there could be a late increase in risk after vector and host populations are re-established. In addition, risk could increase when people are relocated to areas where transmission is intense. Jennifer A. Lehman,* Alison F. Hinckley,* Krista L. Kniss,* Roger S. Nasci,* Theresa L. Smith,* Grant L. Campbell,* and Edward B. Hayes* *Centers for Disease Control and Prevention, Fort Collins, Colorado, USA
منابع مشابه
Update to CDC's Sexually transmitted diseases treatment guidelines, 2010: oral cephalosporins no longer a recommended treatment for gonococcal infections.
Gonorrhea is a major cause of serious reproductive complications in women and can facilitate human immunodeficiency virus (HIV) transmission. Effective treatment is a cornerstone of U.S. gonorrhea control efforts, but treatment of gonorrhea has been complicated by the ability of Neisseria gonorrhoeae to develop antimicrobial resistance. This report, using data from CDC's Gonococcal Isolate Surv...
متن کاملOpen Study of the Safety and Efficacy of a Single Oral Dose of Cefixime for the Treatment of Gonorrhea in Pregnancy
OBJECTIVE The intent of this study was to determine the efficacy and tolerance of single dose oral cefixime use in the treatment of pregnant women with endocervical gonococcal carriage. METHODS A retrospective review of clinic records over a 3 year period identified patients treated with a single 400 mg dose of cefixime for gonorrhea during pregnancy. Side effects and subsequent gonococcal ca...
متن کاملGrepafloxacin Versus Cefixime as Single-Dose Therapy for Uncomplicated Gonorrhea in Women
OBJECTIVE To compare the efficacy and tolerance of single-dose grepafloxacin with cefixime for treatment of uncomplicated gonorrhea in women. METHODS Women attending nine sexually-transmitted-disease clinics in the United States who had suspected uncomplicated gonorrhea were enrolled in an open study. Participants were randomized to receive single oral doses of grepafloxacin (400 mg) or cefix...
متن کاملCephalosporin-resistant gonorrhea in North America.
GONORRHEA HAS AFFECTED HUMANS FOR CENTUries and remains common. Worldwide, an estimated 106.1 million cases occur annually. In 2011, gonorrhea again was the second most commonly reported notifiable infection in the United States with 321 849 cases reported. Because gonorrhea often can be asymptomatic, the true disease burden may be closer to 700 000. Gonorrhea disproportionately affects racial,...
متن کاملSingle-dose oral cefixime versus amoxicillin plus probenecid for the treatment of uncomplicated gonorrhea in men.
In this randomized study, a single 800-mg oral dose of cefixime cured 96 of 97 men with uncomplicated gonococcal urethritis, compared with 44 cures of 46 men who received standard therapy with amoxicillin (3 g) plus probenecid (1 g). Both regimens were ineffective against coexistent infection with Chlamydia trachomatis and Ureaplasma urealyticum. Cefixime was well tolerated, and all side effect...
متن کاملComparison of single-dose oral grepafloxacin with cefixime for treatment of uncomplicated gonorrhea in men. The STD Study Group.
In a randomized open study, 351 male patients with uncomplicated gonorrhea were given single oral doses of grepafloxacin (400 mg) or cefixime (400 mg). In the 299 microbiologically evaluable patients, urethral infections were cured in 99% (147 of 149) of those receiving grepafloxacin and 97% (145 of 150) of those given cefixime. Eradication rates for both regimens were 100% in the 16% (47 of 29...
متن کامل