HIGHLIGHTED TOPIC Hypoxia Exploratory proteomic analysis of hypobaric hypoxia and acute mountain sickness in humans
نویسندگان
چکیده
Colleen G. Julian, Andrew W. Subudhi, Ryan C. Hill, Megan J. Wilson, Andrew C. Dimmen, Kirk C. Hansen, and Robert C. Roach Altitude Research Center, Department of Emergency Medicine, University of Colorado Denver, Aurora, Colorado; Department of Medicine, University of Colorado Denver, Aurora, Colorado; Department of Biology, University of Colorado, Colorado Springs, Colorado; and Department of Biochemistry and Molecular Genetics, University of Colorado Denver, Aurora, Colorado
منابع مشابه
Exploratory proteomic analysis of hypobaric hypoxia and acute mountain sickness in humans.
Our objective in this exploratory study was to identify novel biomarkers of importance for acute mountain sickness (AMS) using discovery-based proteomic methods. Peripheral blood samples were collected and AMS symptoms were assessed in 20 healthy volunteers prior to [-15 h (baseline) and 0 h; 1,609 m; barometric pressure = 625 mmHg] and after a 9-h exposure to hypobaric hypoxia (9 h; 4,875 m; b...
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Introduction: Chronic mountain sickness (CMS) represents a syndrome of secondary polycythemia along with thrombocytopenia, altered hemorheology, pulmonary and systemic hypertension, and congestive heart failure, occurring due to hypobaric hypoxia-anoxia-induced erythropoiesis reported in both native mountain residents and new climbers after prolonged stays at high and extreme a...
متن کاملHIGHLIGHTED TOPIC Hypoxia Acute mountain sickness, chemosensitivity, and cardiorespiratory responses in humans exposed to hypobaric and normobaric hypoxia
Normand A. Richard, Inderjeet S. Sahota, Nadia Widmer, Sherri Ferguson, A. William Sheel, and Michael S. Koehle School of Kinesiology, University of British Columbia, Vancouver, British Columbia, Canada; Department of Medicine, University of British Columbia, Vancouver, British Columbia, Canada; Environmental Medicine and Physiology Unit, Faculty of Science, Simon Fraser University, Burnaby, Br...
متن کاملAcute mountain sickness, chemosensitivity, and cardiorespiratory responses in humans exposed to hypobaric and normobaric hypoxia.
We examined the control of breathing, cardiorespiratory effects, and the incidence of acute mountain sickness (AMS) in humans exposed to hypobaric hypoxia (HH) and normobaric hypoxia (NH), and under two control conditions [hypobaric normoxia (HN) and normobaric normoxia (NN)]. Exposures were 6 h in duration, and separated by 2 wk between hypoxic exposures and 1 wk between normoxic exposures. Be...
متن کاملPrediction of susceptibility to acute mountain sickness by SaO2 values during short-term exposure to hypoxia.
Prediction of the development of acute mountain sickness (AMS) in individuals going to high altitudes is still a matter of debate. Whereas some studies found that subjects with a blunted hypoxic ventilatory response (HVR) are predisposed to AMS, others did not. However, the HVR has often been determined under very acute (5 to 10 min) isocapnic hypoxia without consideration of the subsequent hyp...
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