A C-14 labeled Py-Im polyamide localizes to a subcutaneous prostate cancer tumor.
نویسندگان
چکیده
In an effort to quantitate Py-Im polyamide concentrations in vivo, we synthesized the C-14 radioactively labeled compounds 1-3, and investigated their tumor localization in a subcutaneous xenograft model of prostate cancer (LNCaP). Tumor concentrations were compared with representative host tissues, and exhibited a certain degree of preferential localization to the xenograft. Compound accumulation upon repeated administration was measured. Py-Im polyamide 1 was found to accumulate in LNCaP tumors at concentrations similar to the IC50 value for this compound in cell culture experiments.
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ورودعنوان ژورنال:
- Bioorganic & medicinal chemistry
دوره 22 16 شماره
صفحات -
تاریخ انتشار 2014