Distinct functions for Stat1 and PU.1 in transcriptional activation of FcγRI promoter Running title: Stat1 and PU.1 in FcγRI promoter activation
نویسندگان
چکیده
Institute of Medical Technology, University of Tampere, FIN-33014 Tampere, Finland Department of Molecular Genetics and Microbiology, Shands Cancer Center, University of Florida, Gainesville, FL 32610 Abramson Family Cancer Research Institute, Howard Hughes Medical Institute, University of Pennsylvania Cancer Center, Philadelphia, PA 19104 Department of Clinical Microbiology, Tampere University Hospital, FIN-33521 Tampere, Finland
منابع مشابه
Distinct functions for signal transducer and activator of transcription 1 and PU.1 in transcriptional activation of Fc gamma receptor I promoter.
The myeloid cell-specific expression and interferon-gamma (IFN-gamma) induction of Fc gamma receptor I (FcgammaRI) requires cooperation between PU.1 and signal transducer and activator of transcription 1 (Stat1) by means of mechanisms that are unknown. We found that PU.1 and Stat1 mediated distinct functions in the activation of FcgammaRI promoter. The basal activity of the natural FcgammaRI pr...
متن کاملBrief report Distinct functions for signal transducer and activator of transcription 1 and PU.1 in transcriptional activation of Fc receptor I promoter
The myeloid cell–specific expression and interferon(IFN) induction of Fc receptor I (Fc RI) requires cooperation between PU.1 and signal transducer and activator of transcription 1 (Stat1) by means of mechanisms that are unknown. We found that PU.1 and Stat1 mediated distinct functions in the activation of Fc RI promoter. The basal activity of the natural Fc RI promoter was strictly dependent o...
متن کاملMolecular basis of Stat1 and PU.1 cooperation in cytokine-induced Fcgamma receptor I promoter activation.
The high-affinity receptor for IgG (FcgammaRI) is a myeloid cell-specific and IFN-gamma-induced gene, and thereby serves as a paradigm for cytokine-induced cell type-specific gene responses. The expression of FcgammaRI is regulated by PU.1 and Stat1 transcription factors. We established an experimental model to analyze the individual functions of Stat1 and PU.1 in cytokine-induced transcription...
متن کاملAnaplasma phagocytophilum modulates gp91phox gene expression through altered interferon regulatory factor 1 and PU.1 levels and binding of CCAAT displacement protein.
Infection of neutrophil precursors with Anaplasma phagocytophilum, the causative agent of human granulocytic ehrlichiosis, results in downregulation of the gp91(phox) gene, a key component of NADPH oxidase. We now show that repression of gp91(phox) gene transcription is associated with reduced expression of interferon regulatory factor 1 (IRF-1) and PU.1 in nuclear extracts of A. phagocytophilu...
متن کاملCancer Therapeutics Insights REST Negatively and ISGF3 Positively Regulate the Human STAT1 Gene in Melanoma
STAT1 plays a pivotal role in signal transduction and transcriptional activation in response to type I and II IFNs. Regulation of STAT1 expression has significant consequences in human cancer cells, where STAT1 deficiencies have been associated with cellular resistance to type I IFN. Distinct promoter, enhancer, and repressor regions have previously beendescribed in the regulatory part of the h...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
عنوان ژورنال:
دوره شماره
صفحات -
تاریخ انتشار 2002