Endocytic receptor for pro-coagulant factor VIII: relevance to inhibitor formation.
نویسندگان
چکیده
The immunogenicity of therapeutic factor VIII (FVIII) in patients with haemophilia A remains a critical issue in patient management. This review describes the immunological processes involved in the activation of the immune system against FVIII, with a particular focus on the role of endocytic receptors for the recognition of FVIII by antigen-presenting cells.
منابع مشابه
Detection of Factor VIII Inhibitors in Hemophilia A Patients
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ورودعنوان ژورنال:
- Thrombosis and haemostasis
دوره 104 6 شماره
صفحات -
تاریخ انتشار 2010