Development and preliminary results of an endoscopic Raman probe for potential in vivo diagnosis of lung cancers.

نویسندگان

  • Michael A Short
  • Stephen Lam
  • Annette McWilliams
  • Jianhua Zhao
  • Harvey Lui
  • Haishan Zeng
چکیده

A near-infrared Raman system was developed to collect real-time in vivo human lung spectra. The excitation light and the emission were guided to and from the tissue surface by a reusable fiber catheter passed down the instrument channel of a bronchoscope. Two-stage filtering was used to reduce laser noise, fluorescence, and Raman emissions from the fibers. A second fiber bundle guided the emission to a spectrometer where the fibers, in a round packing geometry, were spread out to form a parabolic arc that improved the signal-to-noise ratio 20-fold, facilitating real-time spectral measurements. Preliminary clinical tests show that clear and reliable Raman spectra can be obtained.

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عنوان ژورنال:
  • Optics letters

دوره 33 7  شماره 

صفحات  -

تاریخ انتشار 2008