Title : Sphingosine - 1 - Phosphate ( S 1 P ) Stimulation Decreases Vascular Endothelial Growth Factor ( VEGF ) and Interleukin - 8 ( IL - 8 ) Secretion in Follicular Thyroid Cancer
نویسنده
چکیده
Background: An estimated 37,340 new cases of thyroid cancer will be diagnosed in 2008. As high as Women will count for 75% of these new cases and over 50% of deaths from thyroid cancer. Although thyroid cancer has an excellent prognosis, an important subset is difficult to treat and radioresistant. Angiogenesis is critical for tumor growth. VEGF and IL8 are proangiogenic factors. S1P is a bioactive lipid involved in angiogenesis and an emerging target for cancer therapies.
منابع مشابه
Sphingosine-1-Phosphate (S1P) Stimulation Decreases Vascular Endothelial Growth Factor (VEGF) and Interleukin-8 (IL-8) Secretion in Follicular Thyroid Cancer Cell Lines in Vitro Authors: A. C. Grover and P. J. Yannie Departments: Surgery
Background: An estimated 37,340 new cases of thyroid cancer will be diagnosed in 2008. As high as Women will count for 75% of these new cases and over 50% of deaths from thyroid cancer. Although thyroid cancer has an excellent prognosis, an important subset is difficult to treat and radioresistant. Angiogenesis is critical for tumor growth. VEGF and IL8 are proangiogenic factors. S1P is a bioac...
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