CLINICAL TRIALS AND OBSERVATIONS Monosomy 7 and deletion 7q in children and adolescents with acute myeloid leukemia: an international retrospective study
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چکیده
Henrik Hasle,1 Todd A. Alonzo,2 Anne Auvrignon,3 Catherine Behar,4 Myron Chang,5 Ursula Creutzig,6 Alexandra Fischer,7 Erik Forestier,8 Alcira Fynn,9 Oskar A. Haas,10,11 Jochen Harbott,12 Christine J. Harrison,13 Nyla A. Heerema,14 Marry M. van den Heuvel-Eibrink,15,16 Gertjan J. L. Kaspers,17 Franco Locatelli,18 Peter Noellke,7 Sophia Polychronopoulou,19 Yaddanapudi Ravindranath,20 Bassem Razzouk,21 Dirk Reinhardt,22 Natalia N. Savva,23 Batia Stark,24 Stefan Suciu,25 Ichiro Tsukimoto,26 David K. Webb,27 Dorora Wojcik,28 William G. Woods,29 Martin Zimmermann,22 Charlotte M. Niemeyer,7 and Susana C. Raimondi30
منابع مشابه
CLINICAL OBSERVATIONS, INTERVENTIONS, AND THERAPEUTIC TRIALS Risk factors for evolution of acquired aplastic anemia into myelodysplastic syndrome and acute myeloid leukemia after immunosuppressive therapy in children
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Monosomal karyotype (MK), defined as > 2 autosomal monosomies or a single monosomy in the presence of other structural abnormalities, was confirmed by several studies to convey an extremely poor prognosis in patients with acute myeloid leukemia (AML) with a 4-year overall survival after diagnosis of < 4%. A recent investigation by the Southwest Oncology Group found that the only MK patients ali...
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Mutations of nicotinamide adenine dinucleotide phosphate-dependent isocitrate dehydrogenase gene (IDH1) have been identified in patients with gliomas. Recent genomewide screening also revealed IDH1 mutation as a recurrent event in acute myeloid leukemia (AML), but its clinical implications in AML are largely unknown. We analyzed 493 adult Chinese AML patients in Taiwan and found 27 patients (5....
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