A novel mechanism for vasoconstrictor action of 8-isoprostaglandin F2a on retinal vessels
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چکیده
ISABELLE LAHAIE,1 PIERRE HARDY,1 XIN HOU,1 HAROUTIOUN HASSÉSSIAN,2 PIERRE ASSELIN,1 PIERRE LACHAPELLE,3 GUILLERMINA ALMAZAN,4 DAYA R. VARMA,4 JASON D. MORROW,5 L. JACKSON ROBERTS II,5 AND SYLVAIN CHEMTOB1,4 1Departments of Pediatrics, Ophthalmology, and Pharmacology, Research Center of Hôpital Sainte Justine, University of Montréal, 2Department of Ophthalmology, Guy-Bernier Research Center of Hôpital Maisonneuve-Rosemont, University of Montréal, Montreal, Quebec H3T 1C5; 3Department of Ophthalmology, Montreal Children’s Hospital Research Center, McGill University, 4Department of Pharmacology and Therapeutics, McGill University, Montreal, Quebec H3A 2B2, Canada; and 5Departments of Pharmacology and Medicine, Vanderbilt University, Nashville, Tennessee 37232
منابع مشابه
A novel mechanism for vasoconstrictor action of 8-isoprostaglandin F2α on retinal vessels.
Using a video-imaging technique, we characterized the effects of 8-isoprostaglandin F2α(8-iso-PGF2α) on retinal vasculature from piglets. 8-Iso-PGF2α potently contracted (EC50 = 5.9 ± 0.5 nM) retinal vessels. These effects were completely antagonized by the cyclooxygenase inhibitor indomethacin, the thromboxane synthase blocker CGS-12970, the thromboxane receptor antagonist L-670596, and the pu...
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BACKGROUND/AIMS The authors investigated the concentrations of 8-isoprostaglandin F(2a), a marker of oxidative stress in vivo, and ascorbic acid, a protectant against oxidative damage, in the aqueous humour of patients with exfoliation syndrome (XFS) and cataract and compared the results with those in age matched patients with cataract, but without XFS, to determine whether XFS is associated wi...
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