Association between psychological symptoms in adults and growth in early life: longitudinal follow up study.

OBJECTIVES To test the hypothesis that birth weight for gestational age and weight gain in early childhood have a long term association with psychological distress in adults. DESIGN Longitudinal study of 1958 birth cohort followed to age 42 years. SETTING Population based birth cohort study. PARTICIPANTS 9731 cohort members with valid perinatal, postnatal, and adult data. MAIN OUTCOME MEASURES Malaise inventory scores measured at ages 23, 33, and 42 years. Generalised estimating equations approach used to analyse repeated measures. RESULTS Psychological distress score was inversely related to birthweight z score and weight gain from birth to the age of 7 years. A unit increase in birthweight z score or childhood weight gain was associated with a mean reduction in psychological distress score of 0.10 (95% confidence interval 0.05 to 0.15) and 0.06 (0.02 to 0.10), respectively. Birth weight and weight gain were also inversely related to the odds of having a high level of psychological distress, with odds ratios being 0.90 (0.85 to 0.95) and 0.93 (0.89 to 0.98), respectively. CONCLUSIONS Psychological health in adults is related to fetal growth and growth in early childhood.