Effect of anticonvulsants on plasma testosterone and sex hormone binding globulin levels.

نویسندگان

  • J M Barragry
  • H L Makin
  • D J Trafford
  • D F Scott
چکیده

Plasma sex hormone binding globulin (SHBG) and testosterone levels were measured in 29 patients with epilepsy (16 men and 13 women), most of them on chronic therapy with anticonvulsant drugs. Sex hormone binding globulin concentrations were increased in both sexes and testosterone levels in male patients. It is postulated that anticonvulsants may induce hepatic synthesis of SHBG.

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منابع مشابه

Sex hormones, sexual activity and plasma anticonvulsant levels in male epileptics.

Testosterone, LH, FSH, PRL, and sex hormone binding globulin (SHBG) were measured in 72 male epileptic patients on chronic anticonvulsant drug regimes. Sexual activity was estimated and plasma anticonvulsants measured. Total testosterone (TT), LH, FSH, PRL, and SHBG were increased; free testosterone (FT) was decreased. Sexual activity appeared diminished particularly in relation to reduced FT.

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عنوان ژورنال:
  • Journal of neurology, neurosurgery, and psychiatry

دوره 41 10  شماره 

صفحات  -

تاریخ انتشار 1978