Successful treatment of methicillin-resistant Staphylococcus epidermidis prosthetic joint infection with telavancin.

pneumoniae ALI belonged to ST743, which is a newly identified sequence type. PCR mapping performed as described previously identified the blaOXA-48 gene that was located on the composite transposon Tn1999. Isolate ALI also possessed an intrinsic blaSHV-28 gene encoding a narrow-spectrum b-lactamase of the SHV-1 type. Plasmid location of the blaOXA-48 gene was confirmed by mating-out assays followed by plasmid analysis as described. PCR assays using a set of primers designed from the reference blaOXA-48-positive plasmid confirmed that blaOXA-48 was located on the IncL/M-type 62 kb epidemic plasmid. No other antibiotic resistance marker was co-transferred, as observed previously. This study reports on the first OXA-48-producing K. pneumoniae from the Arabian peninsula. That finding is not so surprising considering that recent studies have indicated that North African countries, which represent an important source of the immigrant population of Kuwait, are endemic for OXA-48 producers. Such a finding further highlights the current widespread nature of OXA-48 producers, and further legitimates the current policies implemented in France to screen patients for multidrug-resistant isolates who have been hospitalized abroad.