Mice During Inhibition of Nitric Oxide Synthesis : Evidence for an Endothelin-Mediated Angiotensin II Activates Collagen Type I Gene in the Renal Vasculature of Transgenic
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چکیده
Jean-Jacques Boffa, Pierre-Louis Tharaux, Sandrine Placier, Raymond Ardaillou, Jean-Claude Mechanism Mice During Inhibition of Nitric Oxide Synthesis : Evidence for an Endothelin-Mediated Angiotensin II Activates Collagen Type I Gene in the Renal Vasculature of Transgenic Print ISSN: 0009-7322. Online ISSN: 1524-4539 Copyright © 1999 American Heart Association, Inc. All rights reserved. is published by the American Heart Association, 7272 Greenville Avenue, Dallas, TX 75231 Circulation doi: 10.1161/01.CIR.100.18.1901 1999;100:1901-1908 Circulation. http://circ.ahajournals.org/content/100/18/1901 World Wide Web at: The online version of this article, along with updated information and services, is located on the
منابع مشابه
Angiotensin II activates collagen type I gene in the renal vasculature of transgenic mice during inhibition of nitric oxide synthesis: evidence for an endothelin-mediated mechanism.
BACKGROUND Hypertension is frequently associated with renal vascular fibrosis. The purpose of this study was to investigate whether angiotensin II (Ang II) is involved in this fibrogenic process. METHODS AND RESULTS Experiments were performed on transgenic mice harboring the luciferase gene under the control of the collagen I-alpha(2) chain promoter [procolalpha(2)(I)]. Hypertension was induc...
متن کاملAngiotensin II Activates Collagen Type I Gene in the Renal Cortex and Aorta of Transgenic Mice through Interaction with Endothelin and TGF- FADI FAKHOURI,* SANDRINE PLACIER,* RAYMOND ARDAILLOU,* JEAN-CLAUDE DUSSAULE, and CHRISTOS CHATZIANTONIOU*
Hypertension is frequently associated with the development of renal vascular fibrosis. This pathophysiologic process is due to the abnormal formation of extracellular matrix proteins, mainly collagen type I. In previous studies, it has been observed that the pharmacologic blockade of angiotensin II (Ang II) or endothelin (ET) blunted the development of glomeruloand nephroangiosclerosis in nitri...
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BACKGROUND Renal fibrosis, a common complication of hypertension and diabetes is considered as a non-curable disease and is characterized by the abnormal accumulation of collagen I within the kidney. Chronic inhibition of nitric oxide (NO) synthesis is a model of hypertension associated with the development of nephroangiosclerosis. The present study investigated whether halt of NO inhibition le...
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In previous studies, we have observed that endothelin participates in the progression of renal vascular and glomerular fibrosis during hypertension by activating collagen I gene synthesis. The present study investigated whether administration of endothelin receptor antagonists leads to the regression of renal sclerotic lesions. Experiments were performed in transgenic mice harboring the lucifer...
متن کاملNitric oxide inhibition induces early activation of type I collagen gene in renal resistance vessels and glomeruli in transgenic mice. Role of endothelin.
Hypertension is often associated with the development of nephroangio- and glomerulo-sclerosis. This pathophysiological process is due to increased extracellular matrix protein, particularly type I collagen, accumulation. This study investigated whether nitric oxide (NO) synthesis is involved in the mechanism(s) regulating activation of the collagen I gene in afferent arterioles and glomeruli. E...
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