Cancer Therapy: Clinical Denosumab Induces Tumor Reduction and Bone Formation in Patients with Giant-Cell Tumor of Bone
نویسندگان
چکیده
Purpose:Giant-cell tumor of bone (GCTB) is a locally aggressive, benign osteolytic tumor in which bone destruction is mediated by RANK ligand (RANKL). The RANKL inhibitor denosumab is being investigated for treatment of GCTB. We describe histologic analyses of GCTB tumor samples from a phase II study of
منابع مشابه
Denosumab in Patients with Giant Cell Tumor and Its Recurrence: A Systematic Review
Recent studies suggest that Denosumab reduces tumor size, therefore, makes the surgery easier with lowermorbidity. However, some studies have reported several complications for this drug. So, this systematic reviewwas performed to determine the effectiveness and safety of Denosumab in reducing bone destructions activity ofgiant cell tumor and skeletal-related events (SRE) in affected patients w...
متن کاملDenosumab induces tumor reduction and bone formation in patients with giant-cell tumor of bone.
PURPOSE Giant-cell tumor of bone (GCTB) is a locally aggressive, benign osteolytic tumor in which bone destruction is mediated by RANK ligand (RANKL). The RANKL inhibitor denosumab is being investigated for treatment of GCTB. We describe histologic analyses of GCTB tumor samples from a phase II study of denosumab in GCTB. EXPERIMENTAL DESIGN Adult patients with recurrent or unresectable GCTB ...
متن کاملGiant Cell Tumor of the Sacrum: Series of 19 Patients and Review of the Literature
There are still some debates regarding the best treatment of Giant Cell Tumor (GCT) of the sacrum. Since GCT of this location is rare, therapeutic strategies are mainly based on the treatment of GCT in other anatomic locations. The objective of this study was to evaluate the oncologic and clinical results of surgical management of sacral GCT with and without local adjuvant therapy. Medical reco...
متن کاملThe Epidemiologic Characteristics, Clinical Behavior and Outcome of the Giant Cell Tumor of Bone: a Retrospective Single-Center Study
Abstract Objects:Giant cell tumor of bone (GCTB) isa locally aggressive lesion with unpredictable behavior. Here, we aim to evaluate the epidemiological characteristics, clinical and functional outcome of GCTB in a relatively large series of patients. Methods:Patients with the diagnosis of GCTB were included in this retrospective study.Surgical options included extended curettage wh...
متن کاملThe Most Appropriate Reconstruction Method Following Giant Cell Tumor Curettage: A Biomechanical Approach
Giant cell tumor (GCT) is a primary and benign tumor of bone, albeit locally aggressive in some cases, such as in the epi-metaphyseal region of long bones, predominantly the distal end of femur and proximal end of tibia (1). There are a variety of treatments for a bone affected by GCT, ranging from chemotherapy, radiotherapy, embolization, and cryosurgery, to surgery with the use of chemical or...
متن کامل