Pediatric brainstem tumors. Classifications, investigations, and growth patterns.
نویسندگان
چکیده
Brainstem gliomas occur in 10-20% of brain tumors in pediatrics. Over the past 3 decades, the treatment of brainstem gliomas has significantly progressed as a result of the gradual advancements in microsurgical techniques, sophisticated imaging technology and, most importantly, the availability of MRI. In this article, we review the current literature on brainstem gliomas and cover diagnosis, imaging, classification, and management. Surgical approaches and intraoperative modalities to tackle operable cases of brainstem gliomas will be discussed in a follow up article.
منابع مشابه
Neuropathological and neuroradiological spectrum of pediatric malignant gliomas: correlation with outcome.
BACKGROUND The diagnostic accuracy and reproducibility for glioma histological diagnosis are suboptimal. OBJECTIVE To characterize radiological and histological features in pediatric malignant gliomas and to determine whether they had an impact on survival. METHODS We retrospectively reviewed a series of 96 pediatric malignant gliomas. All histological samples were blindly and independently...
متن کاملRole of surgery in brainstem gliomas.
For a pediatric neurosurgeon, one of the most frustrating experiences is managing a child with brainstem glioma. With a median survival of less than 12 months, these children are often managed with radiation therapy and sometimes with chemotherapy. Most tumors in the pediatric population are of diffuse variety (60-75% of the brainstem tumors) occurring in the pons and only a selective percentag...
متن کاملFavorable outcome with conservative treatment for children with low grade brainstem tumors.
BACKGROUND Pediatric brainstem tumors (BST) comprise a heterogeneous group of entities. Data regarding treatment options and outcome of BST, specifically brainstem low grade tumors (BSLGT) are limited. In order to better define risk groups and evaluate treatment options for pediatric BST, we performed a comprehensive analysis of all BST patients treated in our hospital during the MRI era. PRO...
متن کاملUnusual Radiologic Findings and Pathologic Growth Patterns on Choroid Plexus Papillomas
OBJECTIVE Choroid plexus papillomas (CPPs) are generally regarded as benign tumors with typical radiologic and pathologic findings. However, they sometimes have unusual findings. We have analyzed radiologic findings and pathologic growth patterns on CPPs. METHODS The study group included 5 male and 5 female patients (age range, 3 months to 58 years : median, 29 years). The study group include...
متن کاملEpidermal growth factor receptor expression and gene amplification in high-grade non-brainstem gliomas of childhood.
Epidermal growth factor receptor (EGFR) is commonly overexpressed in adult high-grade gliomas. Forty to 50% of such tumors demonstrate amplification of the EGFR gene, often with rearrangement and constitutive activation of the gene product, suggesting that EGFR might play a role in the malignant progression of a subset of these neoplasms. In this regard, several groups have shown that overexpre...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید
ثبت ناماگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید
ورودعنوان ژورنال:
- Neurosciences
دوره 19 2 شماره
صفحات -
تاریخ انتشار 2014