α-Alkylation of a norbornene-derived tricyclic ketone: are steric factors really in control?
نویسنده
چکیده
Density functional theory (DFT) has been used to investigate the α-alkylation of a chiral tricyclic ketone. These calculations reveal that torsional strain and a strong conformational preference, rather than steric influences, are responsible for the high levels of observed stereoselectivity and suggest a way by which alternative stereoisomers could be accessed.
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ورودعنوان ژورنال:
- Chemical communications
دوره 51 11 شماره
صفحات -
تاریخ انتشار 2015