Downregulation of microRNAs 145-3p and 145-5p is a Long-Term Predictor of Postmenopausal Breast Cancer Risk: the ORDET prospective study (miRNAS as long-term predictors of breast cancer occurrence)
نویسندگان
چکیده
1 Department of Oncology, Faculty of Health Science, McMaster University, Hamilton, Canada 2 Translational Oncogenomics Unit, Regina Elena Italian National Cancer Institute, Rome, Italy 3 – The Statistics for Integrative Genomics and Methods Advancement Laboratory, Population Genomics Program, Department of Clinical Epidemiology & Biostatistics, Faculty of Health Sciences, McMaster University, Hamilton, Canada 4 Department of Physics of Complex Systems, Weizmann Institute of Science, 76100, Rehovot, Israel 5Department of Preventive and Predictive Medicine, Fondazione Istituto Nazionale Tumori, Milano, Italy 6 Molecular Chemoprevention Group, Molecular Medicine Area, Regina Elena Italian National Cancer Institute, Rome, Italy 7Department of Biological Regulation, Weizmann Institute of Science, 76100, Rehovot, Israel
منابع مشابه
Downregulation of microRNAs 145-3p and 145-5p is a long-term predictor of postmenopausal breast cancer risk: The ORDET prospective study.
BACKGROUND miRNAs have been implicated in the regulation of key metabolic, inflammatory, and malignant pathways; hence, they might be considered both predictors and players of cancer development. METHODS Using a case-control study design nested in the ORDET prospective cohort study, we addressed the possibility that specific mRNAs can serve as early predictors of breast cancer incidence in po...
متن کاملEvaluation of Factors Related to Short-Term and Long-Term Survival of Breast Cancer Patients by Mixture Cure Model
Introduction: Breast cancer is the most common cancer among women. Today, with advancements in medical sciences, increasing the cure probability of patients as well as increasing survival time is an important goal of cancer treatment. Therefore, in this study, in addition to examining patients’ survival, we investigated the cure probability of breast cancer patients and its prognostic factors u...
متن کاملI-44: Long-Term Sequelae of Polycystic OvarySyndrome: Gynecological Cancer
Women with polycystic ovary syndrome (PCOS) have been reported to be at increased risk of a number of gynecological neoplasias, including endometrial, breast, and ovarian cancer. The data supporting an increased risk is almost entirely inferential, based primarily on small case series or shared risk factors. One of the difficulties in exploring the association between these cancers and PCOS, is...
متن کاملI-18: Evaluating Pregnancy and Long-Term Outcomes of ART
When treating infertile couples by assisted reproductive technologies (ART), all aspects of their care in individual clinics should be evaluated frequently. Results should then be compared with other clinics offering similar treatment. Evaluation of possible adverse longterm outcomes can be achieved by pooling results from individual clinics in national, regional and international registers and...
متن کاملApoptosis-related microRNA-145-5p enhances the effects of pheophorbide a-based photodynamic therapy in oral cancer
MicroRNAs (miRNAs) regulate key biological processes, and their aberrant expression has been related to cancer development. Photodynamic therapy (PDT) has emerged as one of the most promising modalities for cancer treatment. However, the application of PDT has been limited to superficially localized human cancerous and precancerous lesions. To increase the usefulness of both PDT and miRNAs in c...
متن کامل