Parvovirus B19 Associated Pure Red Cell Aplasia Associated with R-CHOP Immunochemotherapy for Relapsed B-Cell Non-Hodgkin′S Lymphoma – An Indicator of A Poor Prognosis?

We describe the case of a patient who developed a severe and symptomatic Parvovirus B19 associated anemia during R-CHOP-14 chemoimmunotherapy of a secondary high-grade Non-Hodgkin ́s lymphoma. While lymphoma responded to the initial therapy with R-CHOP plus consolidation radiation therapy, the anemia was interpreted as pure red cell aplasia and responded to treatment with intravenous immunoglobulins. However, both diseases failed to respond to salvage therapies when they recurred simultaneously 4 months after the completion of primary therapy.