CD44: A metastasis driver and therapeutic target
نویسندگان
چکیده
CD44 is the canonical receptor for hyaluronic acid (HA) but is capable of binding other ligands such as osteopontin (OPN) [1-3]. CD44-HA interactions are important mediators of the inflammatory response associated with immune cell development, differentiation, and recruitment [4]. In addition to the standard CD44 receptor (CD44s), CD44 can undergo alternative splicing to form CD44 variants (CD44v) with an altered extracellular stem region which leads to additional interactions with surface bound receptor tyrosine kinases (RTKs) and signaling molecules on neighboring cells, leading to myriad physiologic processes [2]. CD44 also plays a role in pathological processes such as cancer. We have shown the importance interactions between CD44 and hyaluronic acid (HA) in driving growth of tumors that have lost the
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