The effect of retroactivity on the transfer function of a phosphorylation system Citation
نویسندگان
چکیده
It was theoretically shown that impedance-like effects, called retroactivity, in biomolecular circuits can significantly impact the behavior of a system. In this paper, we quantify the effect of retroactivity on the transfer function of a phosphorylation system after linearization of its nonlinear model about a steady state. Our analysis shows that retroactivity shifts the poles of the transfer function toward the low frequency.
منابع مشابه
O-7: Insulin Exerts a Prosurvival Effect on Human Spermatozoa via Mechanisms That Involve the Stimulation of Akt Phosphorylation
Background: The purpose of this study was to examine the impact of Insulin (INS) on human sperm function, in light of a recent proteomic analysis indicating that these cells express the INS receptor (INSR). Materials and Methods: We used Western blot and Immunocytochemical analyses. Results: Immunocytochemical analyses confirmed the presence of INSR in human spermatozoa and localized this recep...
متن کاملAbsolute Acceleration Transfer Function of Secondary Systems Subjected to Multi- Component Earthquakes
The importance of the equipment and secondary systems in seismic design and performance evaluation is well recognized and has been the subject of many studies. In all of these studies, earthquake is considered as a single component, and in most of them the primary system is considered as shear building. Most attention has been concentrated on the response of secondary system and its response sp...
متن کاملAbsolute Acceleration Transfer Function of Secondary Systems Subjected to Multi- Component Earthquakes
The importance of the equipment and secondary systems in seismic design and performance evaluation is well recognized and has been the subject of many studies. In all of these studies, earthquake is considered as a single component, and in most of them the primary system is considered as shear building. Most attention has been concentrated on the response of secondary system and its response sp...
متن کاملModular cell biology: retroactivity and insulation
Modularity plays a fundamental role in the prediction of the behavior of a system from the behavior of its components, guaranteeing that the properties of individual components do not change upon interconnection. Just as electrical, hydraulic, and other physical systems often do not display modularity, nor do many biochemical systems, and specifically, genetic networks. Here, we study the effec...
متن کاملSystem Identification Based on Frequency Response Noisy Data
In this paper, a new algorithm for system identification based on frequency response is presented. In this method, given a set of magnitudes and phases of the system transfer function in a set of discrete frequencies, a system of linear equations is derived which has a unique and exact solution for the coefficients of the transfer function provided that the data is noise-free and the degrees of...
متن کامل