Serum kynurenine in rheumatoid arthritis.
نویسندگان
چکیده
The concentration of kynurenine has been measured in the serum of patients with rheumatoid arthritis and in a control group. The mean serum concentration was 2.27 +/- 0.688 mug/ml for patients with rheumatoid arthritis and 2.95 +/- 0.825 mug/ml for the control group.KYNURENINE: creatinine clearance ratios were higher in the rheumatoid arthritis than in the control group. These data suggest that the increased urinary excretion of kynurenine by patients with rheumatoid arthritis is due at least in part to renal factors.
منابع مشابه
Exploitation of the IDO Pathway in the Therapy of Rheumatoid Arthritis
Indoleamine 2,3-dioxygenase (IDO) is the first and rate-limiting step along the kynurenine pathway and is thought to play a key role in immune homeostasis through depletion of tryptophan and accumulation of kynurenines. In this review we summarize recent research into the possibility of harnessing the IDO pathway for the therapy of rheumatoid arthritis. Inhibition of IDO activity, or knockout o...
متن کاملUrinary tryptophan metabolites in rheumatoid arthritis and some other diseases.
Previous studies from this laboratory have shown that a majority of patients with rheumatoid arthritis excrete abnormally high amounts of 3-hydroxyanthranilic acid and kynurenine (Bett, 1962a, b). A more striking finding was the rise in kynurenine output after tryptophan loading in rheumatoid arthritis. Administration of large doses of pyridoxine over a short period caused a temporary fall in k...
متن کاملUrinary Tryptophan Metabolites in Rheumatoid Arthritis and Some Other Diseases
Previous studies from this laboratory have shown that a majority of patients with rheumatoid arthritis excrete abnormally high amounts of 3-hydroxyanthranilic acid and kynurenine (Bett, 1962a, b). A more striking finding was the rise in kynurenine output after tryptophan loading in rheumatoid arthritis. Administration of large doses of pyridoxine over a short period caused a temporary fall in k...
متن کاملSerum Levels of TNF-α, TNF-αRI, TNF-αRII and IL-12 in Treated Rheumatoid Arthritis Patients
Background: Rheumatoid arthritis (RA) is a chronic multisystem autoimmune disease common in all races and ethnics. Cytokines and cytokines receptors play an important role in RA pathogenesis and clinical presentation. Objective: To investigate the serum levels of TNF-α, TNF-α RI, TNF-α RII and IL-12 in RA patients and healthy control group. Methods: In this study 43 patients fulfilling the revi...
متن کاملEffect of pyridoxine on tryptophan metabolism in rheumatoid arthritis.
In a previous paper (Bett, 1962), it was reported that a majority of patients with rheumatoid arthritis excreted abnormal amounts of the tryptophan metabolites, 3-hydroxyanthranilic acid and kynurenine. In these experiments the most striking difference between control subjects and patients with rheumatoid arthritis was in the urinary kynurenine output after a loading dose of L-tryptophan. This ...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید
ثبت ناماگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید
ورودعنوان ژورنال:
- The Journal of clinical investigation
دوره 48 5 شماره
صفحات -
تاریخ انتشار 1969