Adult Fanconi syndrome progressing to multiple myeloma.
نویسندگان
چکیده
A case of adult Fanconi syndrome is described in which there was urinary excretion of kappa light chains. After 13 years the patient developed overt myeloma. She also developed an adenocarcinoma of the colon and an adenocarcinoma of the parathyroid gland. These findings are discussed in relation to the known association between adult Fanconi syndrome, renal damage, and myeloma.
منابع مشابه
Adult Fanconi syndrome with monoclonal abnormality of immunoglobulin light chain.
Two adult cases of the Fanconi syndrome are described, in each of which there was abnormal urinary excretion of immunoglobulin kappa-chain. The significance of this finding is discussed in relation to the recognized association between multiple myeloma and the Fanconi syndrome.
متن کاملAcquired Fanconi syndrome is an indolent disorder in the absence of overt multiple myeloma.
Adult-acquired Fanconi syndrome (FS) is a rare complication of monoclonal gammopathy. We retrospectively reviewed 32 patients diagnosed with adult-acquired FS between April 1968 and June 2002 at Mayo Clinic (Rochester, MN). At diagnosis, most patients had monoclonal gammopathy of undetermined significance (MGUS) or smoldering multiple myeloma (SMM), with a median creatinine level of 176.8 micro...
متن کاملHeavy-Chain Diseases and Myeloma-Associated Fanconi Syndrome: an Update
The heavy chain diseases (HCDs) are rare B-cell malignancies characterized by the production of a monoclonal immunoglobulin heavy chain without an associated light chain. There are three types of HCD, defined by the class of immunoglobulin heavy chain produced: IgA (α-HCD), IgG (γ-HCD), and IgM (μ-HCD). Alpha-HCD is the most common and usually occurs as intestinal malabsorption in a young adult...
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CREETH, J. M., KEKWICK, R. A., FLYNN, F. V., HARRIS, H., and ROBSON, E. B. (1963): An Ultracentrifuge Study of Urine Proteins with Particular Reference t,o the (Proteinuria of Renal Tubular Disorders, Clin. Chim. Acta, 8, 406. DENT, C. E., and HARRIS, H. (1951): The Genetics of Cystinuria, Ann. Eugen. (Lond.), 16, 60. ENGLE, R. L. Jr., and WALLIS, L. A. (1956): Multiple Myeloma and the Adult Fa...
متن کاملAdult Fanconi syndrome and multiple myelomatosis.
A case is described of a 59-year-old woman presenting with multiple renal tubular defects. The aminoaciduria was of a generalized type. When investigated initially the only feature of myelomatosis was urinary Bence-Jones protein. Two years later radiologically classical multiple myelomatosis developed and rapidly progressed to the patient's death nine months later.
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ورودعنوان ژورنال:
- Journal of clinical pathology
دوره 37 11 شماره
صفحات -
تاریخ انتشار 1984