Who Benefits From PGS?

Whilst new generation sequencing techniques of blastocyst biopsies give rapid response times and are more accurate, we question whether counting chromosomes can lead to an improvement in pregnancy rates and if the cost of trophectoderm biopsy outweighs the benefit in PGS. NGS does not define embryo viability or health, as it does not guarantee that genes are free from DNA breaks/errors, or that they will be expressed/transcribed correctly at the appropriate time in preimplantation development. In addition, PGS cannot detect embryos whose health has been jeopardized by metabolic malfunctions due to epigenetic effects resulting from inherent gamete physiology or sub-optimal in vitro culture and handling.