Free thiomalate in plasma and urine of patients receiving sodium aurothiomalate.
نویسندگان
چکیده
Free thiomalate is measureable in the plasma and urine of patients with rheumatoid arthritis receiving sodium aurothiomalate (Myocrisin). Plasma concentrations and urinary excretion of free thiomalate were measured in 8 patients by high-performance liquid chromatography and electrochemical detection. After an initial intramuscular dose of 20 mg sodium aurothiomalate, free thiomalate was detected in plasma within 15 min, peak levels of up to 600 nmol/l occurring at 30 min. Plasma levels declined rapidly thereafter. During the first 24 h between 2 and 16% of the injected dose of aurothiomalate was recovered in the urine as free thiomalate, maximum excretion occurring during the first hour.
منابع مشابه
Fate of the thiomalate part after intramuscular administration of aurothiomalate in rheumatoid arthritis.
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متن کاملAction of sodium aurothiomalate on erythrocyte membrane.
The number of sulphydryl groups on the erythrocyte membrane has been assessed as a function of nutritional status for two groups of patients, one receiving non-steroidal anti-inflammatory drugs (NSAIDs) and the other receiving sodium aurothiomalate (Myocrisin). The patients receiving NSAIDs had a significantly higher number of sulphydryl groups in both the glucose depleted and glucose activated...
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ورودعنوان ژورنال:
- Annals of the rheumatic diseases
دوره 43 1 شماره
صفحات -
تاریخ انتشار 1984