Lignocaine for topical anesthesia in fiberoptic bronchoscopy.

Accessible online at: www.karger.com/journals/res Fiberoptic bronchoscopy is widely employed by chest physicians around the world and enjoys a remarkable record of safety in a broad spectrum of patiens with a variety of clinical problems. Whether the bronchofiberscope is introduced transorally or transnasally, topical anesthesia is well tolerated. Cocaine, benzocaine, tetracaine, and lignocaine (lidocaine) can be equally effective, but lignocaine has the widest margin of safety and is most commonly used. Ease of administration and low toxicity permit effective diagnostic and therapeutic applications of this important procedure [1]. In a study published in this issue of Respiration by Loukides et al. [2], doses of lignocaine were tabulated and plasma levels measured during and after bronchoscopy in 12 adult patients. 2% lignocaine gel was used intranasally and 2% lignocaine solution was instilled on the larynx and into the trachea in total dose ranging from 500 to 720 mg with the majority being delivered through the bronchoscope. None of their subjects had significant liver disease or heart failure. They measured serum levels of lignocaine at frequent intervals over 2 h and correlated these with delivered dosage. None of their subjects had any adverse reaction, and blood levels in all were maintained well below the range of 5 or 6 Ìg/ml thought to be the toxic threshold. Their results suggested that absorption is less or slower with the nasal gel than with the solution instilled through the bronchoscope. With bronchoscopic delivery, lignocaine can reach terminal bronchioles and alveoli and rapidly enter the circulation. Lignocaine is an aminoethylamide that is distributed in the circulation and metabolized almost exclusively in the liver. In patients with normal liver function, the halflife of the drug is 100–120 min [3]. Clearance may also be decreased in patients with congestive heart failure. The manufacturers’ guidelines emphasize dosage limits. For lidocaine hydrochloride topical solution USP 4%, Roxane Laboratories, Inc., recommend that the maximum dose be ‘kept below 300 mg and in any case should never exceed 4.5 mg/kg (2 mg/lb) of body weight’ [4]. For intravenous injection, which is similar to alveolar instillation, Astra Pharmaceutical USA, Inc., recommend that ‘no more than 200 to 300 mg of lidocaine hydrochloride should be administered during a one hour period’ [5]. Although lignocaine has an enviable safety record, toxic reactions have been reported, usually associated with higher delivered doses or impaired clearance. Wu et al. [6] reported that in a seriously ill 30-year-old woman with acquired immunodeficiency syndrome (AIDS) and chronic renal failure, seizures developed after a total dose of lignocaine of 300–320 mg. Her serum lignocaine level shortly after the seizure was 12.0 Ìg/ml and was still increased at 7.6 Ìg/ml 4 h later. Day et al. [7] reported on the use of lignocaine in a previously healthy 19-year-old female student who was a volunteer in a research investi-