Aurora-A Oncogene in Human Ovarian Cancer
نویسنده
چکیده
presentation 1. Lin Yang, Mei Sun, Hua Yang, Santo V. Nicosia, Jin Q. Cheng, Akt phosphorylates HtrA2/Omi and inhibits its serine protease and proapoptotic activities. 97 American Association for Cancer Research Annual Meeting, 2006. 2. Sungman Park, Santo V. Nicosia, Jin Q. Cheng. Regulation of the pro-apoptotic Gene 24p3 by phosphatidylinositol 3-kinase/Akt through FOXO3a. 97 American Association for Cancer Research Annual Meeting, 2006.
منابع مشابه
Activation and overexpression of centrosome kinase BTAK/Aurora-A in human ovarian cancer.
Previous studies have demonstrated amplification of the centrosome serine/threonine kinase BTAK/Aurora-A in 10-25% of ovarian cancers. However, alterations of BTAK/Aurora-A at kinase and protein levels and its role in ovarian cancer progression have not been well documented. In this study, we examined the kinase activity and protein levels of BTAK/Aurora-A in 92 patients with primary ovarian tu...
متن کاملAurora kinase A promotes ovarian tumorigenesis through dysregulation of the cell cycle and suppression of BRCA2.
PURPOSE Aurora kinase A (Aurora-A) is known to regulate genomic instability and tumorigenesis in multiple human cancers. The underlying mechanism, however, is not fully understood. We examined the molecular mechanism of Aurora-A regulation in human ovarian cancer. EXPERIMENTAL DESIGN Retrovirus-mediated small hairpin RNA (shRNA) was used to silence the expression of Aurora-A in the ovarian ca...
متن کاملBiological characterization of TAK-901, an investigational, novel, multitargeted Aurora B kinase inhibitor.
Protein kinases Aurora A, B, and C play essential roles during mitosis and cell division, are frequently elevated in cancer, and represent attractive targets for therapeutic intervention. TAK-901 is an investigational, multitargeted Aurora B kinase inhibitor derived from a novel azacarboline kinase hinge-binder chemotype. TAK-901 exhibited time-dependent, tight-binding inhibition of Aurora B, b...
متن کاملDNA replication licensing factors and aurora kinases are linked to aneuploidy and clinical outcome in epithelial ovarian carcinoma.
PURPOSE DNA replication licensing factors and Aurora kinases play critical roles in maintaining genomic integrity. We used multiparameter analyses of these cell cycle regulatory proteins to investigate their role in the progression of epithelial ovarian carcinoma (EOC). EXPERIMENTAL DESIGN In a cohort of 143 patients, we linked the protein expression profiles of the proliferation marker Ki67,...
متن کاملOverexpression of the centrosomal protein Aurora-A kinase is associated with poor prognosis in epithelial ovarian cancer patients.
PURPOSE To assess the clinical significance of Aurora-A kinase, a centrosome-regulating serine-threonine kinase, in ovarian carcinoma. EXPERIMENTAL DESIGN Aurora-A kinase expression was assessed by Western blot (cell lines) or immunohistochemistry (high-grade epithelial ovarian cancers), and clinical variables were collected by retrospective chart review. Centrosome amplification was assessed...
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