Influence of testosterone on regulation of ODC, antizyme, and N-SSAT gene expression in mouse kidney
نویسندگان
چکیده
Olivier Levillain,1 Anna Greco,2 Jean-Jacques Diaz,2 Roger Augier,3 Anne Didier,4 Karine Kindbeiter,2 Frédéric Catez,2 and Myriam Cayre3 1Laboratoire de Physiopathologie Métabolique et Rénale, Faculté de Médecine Lyon R. T. H. Laënnec, Institut National de la Santé et de la Recherche Médicale, Unite 499, 69372 Lyon Cedex 08; 2Centre de Génétique Moléculaire et Cellulaire-Unité Mixte de Recherche 5534, 69622 Villeurbanne; 3Laboratoire Neurogenèse et Morphogenèse dans le Développement et chez l’Adulte, 13288 Marseille Cedex 9; and 4Neuroscience et Systèmes Sensoriels, Université Claude Bernard-Centre National de la Recherche Scientifique-Unité Mixte de Recherche 5020, 69366 Lyon Cedex 07, France
منابع مشابه
Influence of testosterone on regulation of ODC, antizyme, and N1-SSAT gene expression in mouse kidney.
Polyamines are involved in the control of the cell cycle and cell growth. In murine kidney, testosterone enhances gene expression of ornithine decarboxylase (ODC), the first enzyme in polyamine biosynthesis. In this study, we document the time course effect of testosterone on 1) gene expression of ODC, antizyme 1 (AZ1), and spermidine/spermine-N1-acetyltransferase (N1-SSAT); 2) ODC activity in ...
متن کاملOrnithine decarboxylase antizyme in kidneys of male and female mice.
Antizyme, a protein inhibitor of ornithine decarboxylase (ODC), was shown to be induced in mouse kidney by repeated injection of putrescine. Antizyme was also present as a complex with ODC in the kidney of untreated mouse. The amount of the renal ODC-antizyme complex was 3-fold higher in male mice than in female mice. On the contrary, the proportion of ODC present as a complex with antizyme was...
متن کاملUp-regulation of spermidine/spermine N1-acetyltransferase (SSAT) expression is a part of proliferative but not anabolic response of mouse kidney.
A differential expression pattern of spermidine/spermine N(1)-acetyltransferase (SSAT), the enzyme critical to proper homeostasis of cellular polyamines, is reported in mouse kidney undergoing hyperplasia and hypertrophy. We have shown that SSAT activity and SSAT mRNA are significantly induced by antifolate CB 3717 and folate that evoke a drug-injury-dependent hyperplasia. In contrast, SSAT act...
متن کاملNuclear and membrane receptor-mediated signalling pathways modulate polyamine biosynthesis and interconversion.
Polyamines play an important role in cell growth and differentiation, while their overproduction has potentially oncogenic consequences. Polyamine homoeostasis, a critical determinant of cell fate, is precisely tuned at the level of biosynthesis, degradation and transport. The enzymes ODC (ornithine decarboxylase), AdoMetDC (S-adenosylmethionine decarboxylase) and SSAT (spermidine/spermine N(1)...
متن کاملTransgenic mouse models for studies of the role of polyamines in normal, hypertrophic and neoplastic growth.
Transgenic mice expressing proteins altering polyamine levels in a tissue-specific manner have considerable promise for evaluation of the roles of polyamines in normal, hypertrophic and neoplastic growth. This short review summarizes the available transgenic models. Mice with large increases in ornithine decarboxylase (ODC), S-adenosylmethionine decarboxylase or antizyme, a protein regulating p...
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