Regional Administration of Antineoplastic Drugs
نویسنده
چکیده
Regional antineoplastic drug delivery is not a new concept. Following the initial recognition that cytotoxic alkylating agents could cause shrinkage of tumor masses and a reduction in the quantity of malignant ascites in patients with advanced ovarian cancer, investigators in the 1950s instilled the drugs directly into the peritoneal cavity in an effort to treat the malignancy (1). Similarly, intrathecal administration of methotrexate in the treatment and prevention of meningeal leukemia (2), intravesical treatment of superficial bladder cancer (3), and direct administration of drugs into blood vessels feeding a localized cancer (4), have been evaluated for more than a decade as therapeutic strategies in the management of malignant disease. In this chapter, the basic pharmacokinetic rationale supporting regional antineoplastic drug delivery will be presented, followed by a discussion of theoretical concerns and practical issues associated with this treatment approach. The chapter will conclude with several examples of regional antineoplastic therapy which have been accepted as “standard of care” in the management of certain clinical settings, and other more experimental strategies employing the regional route of drug delivery.
منابع مشابه
2 Regional Administration of Antineoplastic Drugs
Regional antineoplastic drug delivery is not a new concept. Following the initial recognition that cytotoxic alkylating agents could cause shrinkage of tumor masses and a reduction in the quantity of malignant ascites in patients with advanced ovarian cancer, investigators in the 1950s instilled the drugs directly into the peritoneal cavity in an effort to treat the malignancy (1). Similarly, i...
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