Highlights of the Keystone Symposium: sirtuins in metabolism, aging and disease
نویسندگان
چکیده
From February 12-16, 2012, leading members of the sirtuin scientific community assembled in Tahoe, CA to attend the Keystone Symposium "Sirtuins in Aging, Metabolism, and Disease." It was a vibrant and lively meeting, and in the spirit of Keystone Symposia, both established sirtuin researchers and those new to the field enjoyed a unique opportunity to interact and exchange ideas.
منابع مشابه
Many forkheads in the road to regulation
Introduction Subjects ranging from chromatin remodelling to ageing, from human disease to avian song, and from metabolism and the cell cycle to structural biology and differentiation were all covered at this keystone symposium, and illustrate the diversity of forkhead transcription factors and their regulatory functions. Forkhead transcription factors, or ‘FoX’ proteins, are unified as a family...
متن کاملSirtuins and Aging: is there a Role for Resveratrol?
Prolonged human life duration is consequently associated with a higher incidence of chronic diseases. Aging is a very complex process in which genetic, environmental and cellular pathways are involved. Along with aging, longevity has been linked with Sirtuins. Sirtuin enzymes are a family of highly conserved protein deacetylases that have been linked with calorie restriction and aging by modula...
متن کاملGaining weight: the Keystone Symposium on PPAR and LXR.
The nuclear receptor superfamily consists of 48 mammalian transcription factors that regulate nearly all aspects of development, inflammation, and metabolism. Two subclasses, the Peroxisome Proliferator-Activated Receptors (PPARs) and Liver X Receptors (LXRs), are lipid-sensing receptors that have critical roles in lipid and glucose metabolism. The parallel epidemics of obesity and diabetes shi...
متن کاملHighlights of Keystone symposium ‘Fibrosis: from bench to bedside’
This report is based on the ‘Fibrosis: from bench to bedside’ symposium from the Keystone Symposia meeting series, Keystone, Colorado, 23 to 28 March 2014. It was a fascinating symposium with high quality talks, workshops, and well attended poster sessions.
متن کاملSirtuins, aging, and metabolism.
Sirtuins are nicotinamide adenine dinucleotide (NAD)-dependent protein deacetylases that link protein acetylation, metabolism, aging, and diseases of aging. Sirtuins were initially found to slow aging in lower organisms and more recently shown to mediate many effects of calorie restriction on metabolism and longevity in mammals. This chapter focuses on two key mammalian sirtuins, SIRT1 (which r...
متن کامل