The first organocatalytic carbonyl-ene reaction: isomerisation-free C-C bond formations catalysed by H-bonding thio-ureas
نویسندگان
چکیده
Intramolecular carbonyl ene reactions of highly activated enophiles can be catalysed by H-bonding thio-ureas to give tertiary alcohols in high yields without extensive isomerisation side products. An asymmetric variant of this reaction was realised using a chiral thiourea but was limited by low enantioselectivity (up to 33% e.e.) and low turnover frequencies.
منابع مشابه
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ورودعنوان ژورنال:
- Beilstein Journal of Organic Chemistry
دوره 3 شماره
صفحات -
تاریخ انتشار 2007