Matrix metalloproteinase-9 in an exploratory trial of intravenous minocycline for acute ischemic stroke.

Letter by Lee regarding article, "Matrix metalloproteinase-9 in an exploratory trial of intravenous minocycline for acute stroke".

The Effect of Intravenous Magnesium Sulfate in Improvement of Acute Ischemic Stroke Induced Disability: A Randomized Double Blinded Clinical Trial

Background: Stroke is the third main cause of death and chronic disabilities in adults, which requires finding neuroprotective drugs to reduce its mortality and morbidity.  Objectives: To determine the efficacy of magnesium sulfate as an adjunctive neuroprotective agent in patients with stroke. Materials & Methods: This randomized double-blind clinical trial recruited 120 patients with acute ...

Effects of minocycline plus tissue plasminogen activator combination therapy after focal embolic stroke in type 1 diabetic rats.

BACKGROUND AND PURPOSE Poststroke hyperglycemia is associated with resistance to tissue plasminogen activator (tPA) reperfusion, higher risk of intracerebral hemorrhage, and worse neurological outcomes. In this study, we asked whether minocycline combined with intravenous tPA may ameliorate inflammation and brain injury after focal embolic stroke in type 1 diabetic rats. METHODS Type 1 diabet...

Extension of the thrombolytic time window with minocycline in experimental stroke.

BACKGROUND AND PURPOSE Thrombolysis with tPA is the only FDA-approved therapy for acute ischemic stroke. But its widespread application remains limited by narrow treatment time windows and the related risks of cerebral hemorrhage. In this study, we ask whether minocycline can prevent tPA-associated cerebral hemorrhage and extend the reperfusion window in an experimental stroke model in rats. ...

Effects of Minocycline Plus Tissue Plasminogen Activator Combination

Emerging evidence suggests that stroke comorbidities are associated with tissue plasminogen activator (tPA)–associated intracerebral hemorrhage (ICH) complication, a major limitation of tPA therapy. Clinical investigations have documented a correlation between increased ICH and worse neurological outcomes after tPA thrombolysis in stroke patients with diabetes mellitus or poststroke hyperglycem...