Mediterranean Journal of Hematology and Infectious Diseases

A 71 year old female with multiple myeloma presented with back pain seven year after autologous stem cell transplant. Skeletal bone survey and magnetic resonance imaging did not show a relapse that was evidenced by CT/PET. Lenalidomide as single disappearance of the lesions 6 months later and confirmed after one year at CT/PET. Introduction. Multiple myeloma patients often develop osteolytic lesions that result in debilitating skeletal complications such as fractures, bone pain and hypercalcemia. The development of bone lesions is due to an uncoupled bone remodeling, i.e. the increased osteoclast bone resorption accompanied by a red in bone formation. The usual gold standard technique used at diagnosis is skeletal X-rays survey which is able to give information about radiolucent lesions but do not provide information about bone remodeling or small lesions. Magnetic resonance imaging (MRI) is able to detect smallest lesions present in the soft tissue around the bone and is widely used in the diagnostic process for the evaluation of the spinal cord and pelvis. One of the latest technique used in myeloma is positron emission tomography integrated with computed tomography (CT/PET) which detects with high sensitivity and specificity myeloma bone lesions www.mjhid.org ISSN 2035-3006 ctivity in Multiple Myeloma Relapse E , Giulia Papini, Marzia Defina and Monica Bocchia and Sensorial Sciences, Azienda , Division of Hematology and Transplants, University of Siena, . Tel. +39 at no competing interests exist. 2, 4(1): e2012041, DOI: 10.4084/MJHID.2012.041 10378 ), which permits unrestricted use, distribution, and reproduction in any medium, . agent induced a complete