Optimal Screening Designs with Flexible Cost Structures
نویسندگان
چکیده
We describe results from an algorithm for optimizing a decision-theoretic approach to the design of screening trials, where the goal is to identify promising candidates for future study. Using a highly flexible cost structure, the algorithm can optimize a variety of decision and experimental costs. The designs produced can range from a single stage through to fully sequential, depending on the sampling cost structures. These designs generalize and extend previous results in the area.
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