Profiling at mRNA, protein, and metabolite levels reveals alterations in renal amino acid handling and glutathione metabolism in kidney tissue of Pept2
نویسندگان
چکیده
Isabelle M. Frey, Isabel Rubio-Aliaga, Anne Siewert, Daniela Sailer, Aleksey Drobyshev, Johannes Beckers, Martin Hrabé de Angelis, Julie Aubert, Avner Bar Hen, Oliver Fiehn, Hans M. Eichinger, and Hannelore Daniel Molecular Nutrition Unit, Technical University of Munich, Freising; Institute of Experimental Genetics, GSF, Neuherberg, Germany; Applied Mathematics and Informatics Unit INAPG/ENGREF/INRA, Paris, France; University of California Davis Genome Center, Davis, California; and Laboratory of Bioanalysis, Technical University of Munich, Freising, Germany
منابع مشابه
Profiling at mRNA, protein, and metabolite levels reveals alterations in renal amino acid handling and glutathione metabolism in kidney tissue of Pept2-/- mice.
PEPT2 is an integral membrane protein in the apical membrane of renal epithelial cells that operates as a rheogenic transporter for di- and tripeptides and structurally related drugs. Its prime role is thought to be the reabsorption of filtered di- and tripeptides contributing to amino acid homeostasis. To elucidate the role of PEPT2 in renal amino acid metabolism we submitted kidney tissues of...
متن کاملProfiling at mRNA, protein and metabolite level reveals alterations in renal amino acid handling and glutathione metabolism in kidney tissue of Pept2 mice
PEPT2 is an integral membrane protein in the apical membrane of renal epithelial cells that operates as a rheogenic transporter for diand tripeptides and structurally related drugs. Its prime role is thought to be the reabsorption of filtered diand tripeptides contributing to amino acid homeostasis. To elucidate the role of PEPT2 in renal amino acid metabolism we submitted kidney tissues of wil...
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