The Differential Diagnosis of Feline Anaemia
نویسنده
چکیده
Haematology The mean cell volume (MCV) indicates the average size of red blood cells (RBCs). Regenerative anaemias are usually macrocytic because reticulocytes have high MCVs. However, macrocytosis is not just a feature of regenerative anaemias since non-regenerative anaemias associated with FeLV infection or myelodysplasia can be associated with macrocytosis (Shimoda, et al 2000, Weiss 2006b). The red cell distribution width (RDW) is an estimate of the degree of anisocytosis in a blood sample and is available on some haematology analysers. A high RDW can indicate the presence of increased number of macrocytes, microcytes or both. The mean cell haemoglobin concentration (MCHC) indicates the average concentration of haemoglobin per RBC. A reduced MCHC is termed hypochromic. Regenerative anaemias are usually hypochromic because reticulocytes have higher MCVs and lower haemoglobin content than mature RBCs. Nucleated RBCs (NRBCs) can indicate active regeneration but are also seen with splenic dysfunction, shock, heavy metal toxicity and bone marrow disorders. The presence of polychromasia, anisocytosis and NRBCs on blood smears may indicate regeneration.
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