Modes and nodes explain the mechanism of action of vortioxetine, a multimodal agent (MMA): actions at serotonin receptors may enhance downstream release of four pro-cognitive neurotransmitters.
نویسنده
چکیده
Vortioxetine is an antidepressant with multiple pharmacologic modes of action that enhance release of dopamine, norepinephrine, acetylcholine, and histamine.
منابع مشابه
Modes and nodes explain the mechanism of action of vortioxetine, a multimodal agent (MMA): enhancing serotonin release by combining serotonin (5HT) transporter inhibition with actions at 5HT receptors (5HT1A, 5HT1B, 5HT1D, 5HT7 receptors).
Vortioxetine is an antidepressant that targets multiple pharmacologic modes of action at sites--or nodes--where serotonergic neurons connect to various brain circuits. These multimodal pharmacologic actions of vortioxetine lead to enhanced release of various neurotransmitters, including serotonin, at various nodes within neuronal networks.
متن کاملModes and nodes explain the mechanism of action of vortioxetine, a multimodal agent (MMA): blocking 5HT3 receptors enhances release of serotonin, norepinephrine, and acetylcholine.
Vortioxetine is an antidepressant with multiple pharmacologic modes of action at targets where serotonin neurons connect with other neurons. 5HT3 receptor antagonism is one of these actions, and this leads to increased release of norepinephrine (NE), acetylcholine (ACh), and serotonin (5HT) within various brain circuits.
متن کاملModes and nodes explain the mechanism of action of vortioxetine, a multimodal agent (MMA): modifying serotonin's downstream effects on glutamate and GABA (gamma amino butyric acid) release.
Vortioxetine is an antidepressant with multiple pharmacologic modes of action at targets where serotonin neurons connect with other neurons. These actions modify the release of both glutamate and GABA (gamma amino butyric acid) within various brain circuits.
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Secretin, a peptide hormone of the gastrointestinal system, has been implicated in the etiology of autism. Our laboratory previously demonstrated the expression of secretin and its receptors in specific central neurons, and found for the first time that secretin is neuroactive in the cerebellum. We showed that bath application of secretin facilitated the release of GABA from terminals of basket...
متن کاملActions and release characteristics of secretin in the rat cerebellum
Secretin, a peptide hormone of the gastrointestinal system, has been implicated in the etiology of autism. Our laboratory previously demonstrated the expression of secretin and its receptors in specific central neurons, and found for the first time that secretin is neuroactive in the cerebellum. We showed that bath application of secretin facilitated the release of GABA from terminals of basket...
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ورودعنوان ژورنال:
- CNS spectrums
دوره 20 6 شماره
صفحات -
تاریخ انتشار 2015