Juvenile thyrotoxicosis treated with thiouracil.

Thiouracil in Thyrotoxicosis

Sternal marrow studies in thyrotoxicosis treated with thiouracil and review of literature regarding thiouracil effects on blood.

A review of the available literature to date shows 1914 casest of thyrotoxicosis in which thiouracil was employed. This does not include the use of thiourea or other related compounds nor the use of thiouracil in any condition but thyrotoxicosis. Forty-four cases (1.3 per cent) had resulting agranulocytosis, and of these, i per cent) died because of the agranulocytosis. Ninety-three patients pe...

Antithyroid treatment: a personal series.

Introduction Since the introduction of thiouracil in 1943 antithyroid treatment for thyrotoxicosis has increased widely and has proved safer and more effective in carefully selected cases as the years have passed. Since 1951 carbimazole has been highly favoured in this country, being considered the least toxic agent in large-scale surveys (Burrell, Fraser & Doniach, 1956). Later (Willcox, 1962)...

Thyroidectomy or Thiouracil? *A Paper read to the Bristol Medico—Chirurgical Society on May 12th, 1948.

On two previous occasions, in 19301 and in 1941,2 I have had the honour of reading papers before the Bristol Medico-Chirurgical Society on the surgery of thyrotoxicosis. By that time, operation had become the routine treatment, except in quite mild or very severe cases, and a certain number of children or young women with primary thyrotoxicosis. In 1943, however, thiouracil was introduced by As...

Marine Biological Laboratories.

Scientific Books: Three Mathematical Text-books: PROFESSOR C. N. MOORE. Biochemistry and Morphogenesis: PROFESSOR DOUGLAS WHITAKER .154 Special Articles: Thiouracil in the Treatment of Thyrotoxicosis: DR. ROBERT H. WILLIAMS and DR. GROSVENOR W. BISSELL. Effect of Various Chemical Agents Affecting Permeability of the Mucosa on the Formation of Ulcers: DR. R. L. DRIVER, G. S. DOZIER and H. C. DEN...