Translational Physiology GERD is associated with shortened telomeres in the squamous epithelium of the distal esophagus
نویسندگان
چکیده
Rhonda F. Souza, Tisha Lunsford, Ruben D. Ramirez, Xi Zhang, Edward L. Lee, Yuenan Shen, Charles Owen, Jerry W. Shay, Carmela Morales, and Stuart Jon Spechler Departments of Medicine, Pathology, and Cell Biology, University of Texas Southwestern Medical Center at Dallas and the Veterans Affairs North Texas Health Center, the Harold C. Simmons Comprehensive Cancer Center, Hamon Center for Therapeutic Oncology Research, University of Texas Southwestern Medical Center at Dallas, Dallas; Division of Gastroenterology, Mayo Clinic, Scottsdale, Arizona; Department of Pathology, Howard University College of Medicine, Washington, District of Columbia; and Department of Medicine, Texas Tech University Health Science Center, El Paso, Texas
منابع مشابه
GERD is associated with shortened telomeres in the squamous epithelium of the distal esophagus.
Telomeres are repetitive DNA sequences located at the ends of chromosomes. Telomeres are shortened by repeated cell divisions and by oxidative DNA damage, and cells with critically shortened telomeres cannot divide. We hypothesized that chronic gastroesophageal reflux disease (GERD)-induced injury of the esophageal squamous epithelium results in progressive telomeric shortening that eventually ...
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