Biocompatibility Evaluation of Electrospun Collagen, Gelatin, Polycaprolactone and their Composite Matrices in Rattus Norvegicus
نویسنده
چکیده
The present study records on in vivo evaluation of ve types of electrospun nano brous matrices, viz., collagen, gelatin, polycaprolactone (PCL), collagen-PCL (1:1) and Gelatin-PCL (1:1), prepared with a novel benign solvent in a rat model on wound healing. Granulation tissue formation was observed in the subcutaneous implanted tissue. There was no indication of gross rejection of the implants. The implantation did not result in major necrosis or extensive wound formation at the implantation site. The healing of the sutured incisions was also rapid with no scar formation after seven days of implantation. This study con rms that the ve electrospun matrices were biocompatible and collagen-PCL biomaterial was found superior.
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