Atrial Fibrillation in Transient Ischemic Attack Versus Ischemic Stroke
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چکیده
Atrial fibrillation (AF) increases the risk of stroke 5-fold, but it is effectively reduced by the use of vitamin K antagonist and non–vitamin K antagonist oral anticoagulants (OACs) as recommended in current guidelines. The proportion of AF among patients with ischemic stroke (IS) has been reported to range from 19% to 38%, with variability because of ethnicity, age, and detection mode. Men carry a higher burden of AF, whereas women are more at risk of AF-associated IS, the reasons for which are not completely understood. Whereas the role of AF in IS is well established, there are fewer reports on its contribution to transient ischemic attack (TIA). Substantially lower proportions of AF have been reported for TIA patients ranging from 6.7% to 17.2%. A cardioembolic pathogenesis in TIA according to TOAST (Trial of Org 10172) criteria, that is, AF and other cardiac causes, was reported to be likely in 14.7% to 19.4% of patients, whereas the percentage of patients with undetermined cause could be as high as 46.4%. By evaluating population-based data from a large national register (The Swedish Stroke Register; Riksstroke), we wish to assess the proportion of AF in TIA in comparison to IS and clarify patient characteristics and secondary preventive measures. Methods
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تاریخ انتشار 2016