Human Endothelial cells, through modulation of Cationic Amino Acid
نویسندگان
چکیده
Estradiol augments while progesterone inhibits arginine transport in 1 Human Endothelial cells, through modulation of Cationic Amino Acid 2 Transporter-1. 3 4 Ohad S. Bentur, Doron Schwartz, Tamara Chernichovski, Merav Ingbir, Talia Weinstein, 5 Gil Chernin, Idit F. Schwartz. 6 7 Department of Nephrology, Tel Aviv Sourasky Medical Center, Tel Aviv University, 8 Sackler school of Medicine, Tel Aviv, Israel. 9 10 Abreviated title: Estradiol augments arginine transport in HUVEC 11 Key terms: Estrogen, Progesterone, Arginine transport, Endothelial function 12 Word count: 4564 13 14 Corresponding author 15 Idit F. Schwartz, MD 16 Department of Nephrology 17 Tel Aviv Sourasky Medical Center 18 6 Weizmann street 19 Tel Aviv , ISRAEL, 64239 20 FAX: 972-3-5469825 21 E mail: [email protected] 22 Disclosure Statement: The authors have nothing to disclose. 23 Articles in PresS. Am J Physiol Regul Integr Comp Physiol (June 10, 2015). doi:10.1152/ajpregu.00532.2014
منابع مشابه
Estradiol augments while progesterone inhibits arginine transport in human endothelial cells through modulation of cationic amino acid transporter-1.
Decreased generation of nitric oxide (NO) by endothelial NO synthase (eNOS) characterizes endothelial dysfunction (ECD). Delivery of arginine to eNOS by cationic amino acid transporter-1 (CAT-1) was shown to modulate eNOS activity. We found in female rats, but not in males, that CAT-1 activity is preserved with age and in chronic renal failure, two experimental models of ECD. In contrast, durin...
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