Complete remission of visceral and cutaneous Kaposi´s sarcoma after liver-kidney transplantation.

A 46 year old male with first liver transplantation and second kidney transplantation on the 4th March 2001 with HCV and HBV positive serology, developed back and abdominal pain, weight loss and weakness in August 2001. Physical examination revealed poor general status, pleural effusion, hepatosplenomegaly, ascitis and a 5 mm red nodular lesion in the abdominal skin. Immunosuppressive regimen was thymoglobulin P, MMF and Tacrolimus (FK506). Thorax-abdominal CT scan revealed multiple hypodense areas in the liver (Figure 1). Liver and skin biopses showed the same histological image: spindle-shaped tumor cells surrounding hyperemic vascular slits in association with extravasated erytrocytes, hemosiderin and fibrosis (Figures 2 and 3). Inmunostaining for CD31, CD34 and Factor VIII were positive. HHV-8-DNA-PCR in liver and skin biopses were positive and diagnoses of Kaposi‘s sarcoma was done. It was decided to interrupt MMF adFigure 2. Kaposi’s sarcoma, skin biopsy. HE 100X.