Perspectives Series: Molecular Medicine in Genetically Engineered Animals The Zebrafish: Heritable Disorders in Transparent Embryos

نویسندگان

  • Kenneth R. Chien
  • Jada Lewis
  • Baoli Yang
  • Gregory S. Barsh
  • John Mullins
  • Jamey Marth
  • Wolfgang Driever
  • Mark C. Fishman
چکیده

J. Clin. Invest. © The American Society for Clinical Investigation, Inc. 0021-9738/96/04/1788/07 $2.00 Volume 97, Number 8, April 1996, 1788–1794 “Molecular Medicine in Genetically Engineered Animals” Series Editor, Kenneth R. Chien January 1 Gene modification via “plug and socket” gene targeting................................. Jada Lewis, Baoli Yang, Biological insights through genomics: mouse to man ..................................... Pete Detloff, and Oliver Smithies January 15 Biological insights through genomics: mouse to man ..................................... Edward M. Rubin and Gregory S. Barsh February 1 In vitro differentiation of murine embryonic stem cells: new approaches to old problems .................................................................... Mitchell J. Weiss and Stuart H. Orkin February 15 Genes and physiology: molecular physiology in genetically engineered animals......................................................................................... Kenneth R. Chien March 1 Animal models of human disease for gene therapy........................................ James M. Wilson March 15 Targeted mutagenesis: analysis of phenotype without germ line transmission.................................................................................................... Andras Nagy and Janet Rossant April 1 Transgenesis in the rat and larger mammals.................................................. Linda Mullins and John Mullins April 15 The zebrafish: heritable diseases in transparent embryos ............................. Wolfgang Driever and Mark Fishman May 1 Recent advances in conditional gene mutation by site-directed recombination............................................................................. Jamey Marth Perspectives Series: Molecular Medicine in Genetically Engineered Animals

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Perspectives Series : Molecular Medicine in Genetically Engineered Animals Targeted Mutagenesis : Analysis of Phenotype without Germ Line Transmission

J. Clin. Invest. © The American Society for Clinical Investigation, Inc. 0021-9738/96/03/1360/06 $2.00 Volume 97, Number 6, March 1996, 1360–1365 “Molecular Medicine in Genetically Engineered Animals” Series Editor, Kenneth R. Chien January 1 Gene modification via “plug and socket” gene targeting................................. Jada Lewis, Baoli Yang, Biological insights through genomics: mous...

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Perspectives Series: Molecular Medicine in Genetically Engineered Animals Biological Insights through Genomics: Mouse to Man

Series Editor, Kenneth R. Chien January 1 Gene modification via “plug and socket” gene targeting................................. Jada Lewis, Baoli Yang, Biological insights through genomics: mouse to man ..................................... Pete Detloff, and Oliver Smithies January 15 Biological insights through genomics: mouse to man ..................................... Edward M. Rubin and ...

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Perspectives Series: Molecular Medicine in Genetically Engineered Animals

“Molecular Medicine in Genetically Engineered Animals” Series Editor, Kenneth R. Chien January 1 Gene modification via “plug and socket” gene targeting................................. Jada Lewis, Baoli Yang, Biological insights through genomics: mouse to man ..................................... Pete Detloff, and Oliver Smithies January 15 Biological insights through genomics: mouse to man ......

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Cytochrome C and Caspase-3/7 are Involved in Mycophenolic Acid-induced Apoptosis in Genetically Engineered PC12 Neuronal Cells Expressing the p53 Gene

Mycophenolic acid (MPA) is the active metabolite of mycophenolate mofetil. This study designed to investigate the mechanism of cytotoxicity of MPA on the genetically engineered PC12 Tet Off (PTO) neuronal cells with p53 gene. Alamar Blue (AB) reduction showed concentration-dependent cytotoxicity of MPA on PTO cells with IC50 value of 32.32 ± 4.61 mM. The reactive oxygen species (ROS) generation...

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Cytochrome C and Caspase-3/7 are Involved in Mycophenolic Acid-induced Apoptosis in Genetically Engineered PC12 Neuronal Cells Expressing the p53 Gene

Mycophenolic acid (MPA) is the active metabolite of mycophenolate mofetil. This study designed to investigate the mechanism of cytotoxicity of MPA on the genetically engineered PC12 Tet Off (PTO) neuronal cells with p53 gene. Alamar Blue (AB) reduction showed concentration-dependent cytotoxicity of MPA on PTO cells with IC50 value of 32.32 ± 4.61 mM. The reactive oxygen species (ROS) generation...

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تاریخ انتشار 2013