A Role for the Lateral Olivocochlear Neurons in Auditory Function. Focus on “Selective Removal of Lateral Olivocochlear Efferents Increases Vulnerability to Acute Acoustic Injury”

نویسندگان

  • Colleen G. Le Prell
  • C. G. Le Prell
  • M. Charles Liberman
چکیده

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Selective removal of lateral olivocochlear efferents increases vulnerability to acute acoustic injury.

Cochlear sensory cells and neurons receive efferent feedback from the olivocochlear (OC) system. The myelinated medial component of the OC system and its effects on outer hair cells (OHCs) have been implicated in protection from acoustic injury. The unmyelinated lateral (L)OC fibers target ipsilateral cochlear nerve dendrites and pharmacological studies suggest the LOC's dopaminergic component ...

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Olivocochlear Efferents in Animals and Humans: From Anatomy to Clinical Relevance

Olivocochlear efferents allow the central auditory system to adjust the functioning of the inner ear during active and passive listening. While many aspects of efferent anatomy, physiology and function are well established, others remain controversial. This article reviews the current knowledge on olivocochlear efferents, with emphasis on human medial efferents. The review covers (1) the anatom...

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Role for the Lateral Olivocochlear Neurons in Auditory Function. Focus on “Selective Removal of Lateral Olivocochlear Efferents Increases Vulnerability to Acute Acoustic Injury”

In a paper published in this issue of Journal of Neurophysiology (p. 1775–1785), Darrow and colleagues report that lesions of the lateral superior olive, where the lateral olivocochlear (LOC) efferent originate, enhance auditory evoked potentials in mice. The report also shows that noise-traumatized mouse ears without LOC input are more susceptible to noiseinduced trauma than contralateral ears...

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Role for the lateral olivocochlear neurons in auditory function. Focus on "Selective removal of lateral olivocochlear efferents increases vulnerability to acute acoustic injury".

In a paper published in this issue of Journal of Neurophysiology (p. 1775–1785), Darrow and colleagues report that lesions of the lateral superior olive, where the lateral olivocochlear (LOC) efferent originate, enhance auditory evoked potentials in mice. The report also shows that noise-traumatized mouse ears without LOC input are more susceptible to noiseinduced trauma than contralateral ears...

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Restricted loss of olivocochlear but not vestibular efferent neurons in the senescent gerbil (Meriones unguiculatus)

Degeneration of hearing and vertigo are symptoms of age-related auditory and vestibular disorders reflecting multifactorial changes in the peripheral and central nervous system whose interplay remains largely unknown. Originating bilaterally in the brain stem, vestibular and auditory efferent cholinergic projections exert feedback control on the peripheral sensory organs, and modulate sensory p...

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تاریخ انتشار 2006