Villoglandular Papillary Adenocarcinoma of the Cervix

Cervical cancer encompasses several histologic types, of which Squamous Cell Carcinoma (SCC) is the most common (70 percent). The incidence of invasive cervical adenocarcinoma and its variants has become more common over the past few decades. Currently, this cell type accounts for 10% to 25% of all invasive cervical cancers diagnosed in the United States [1,2]. Most cervical adenocarcinomas are HPV related cancers. HPV 16 is the most common HPV type, with HPV 18 nearly as common and HPV 45 occurring less often [3,4]. They are treated the same at most institutions as the knowledge on the treatment of cervical cancer comes from studies in which the majority of the patients had SCC. Very few studies report separate outcomes for adenocarcinoma, and no prospective study has focused on the treatment of adenocarcinoma as the sole histology. As a result, our understanding of the natural history and optimal management of adenocarcinoma of the cervix is limited.